Enhancing macrophage phagocytosis of cancers by disrupting the SIRPα/CD47 signaling axis and targeting MUC1 antigen.

ABSTRACT: Signal regulatory protein alpha (SIRPα) is an essential immune checkpoint, predominantly expressed on myeloid cells, that binds to CD47. This interaction, termed the 'don't eat me' signal, contributes to immune suppression. Consequently, disruption of the SIRPα/CD47 axis emerges as a promising strategy to intervene in the 'don't eat me' signal, thereby initiating phagocytic activation. Various preclinical and clinical studies employed SIRPα/CD47-targeting molecules to disrupt the SIRPα/CD47 axis to promote cancer phagocytosis. However, concerns regarding their limited efficacy and side effects pose a challenge to applying this approach to cancer therapy. Here, we investigated the role of the SIRPα/CD47 axis in phagocytosis by performing clustered regularly interspaced short palindromic rep

SUBMITTER: Muneekaew S 

PROVIDER: S-EPMC12631164 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature