CDH11 Contributes to Bladder Cancer Progression via Regulation of Mitochondrial Energy Metabolism.

ABSTRACT:

Background

Approximately 83,000 new cases of bladder cancer (BC) in the United States and 23,000 in Japan are confirmed per year, and the number of new BC cases increases every year. While the prognosis for localized cancer is favorable, treatment options for metastatic cancer are limited, and the prognosis is extremely poor.

Aim

Although the prevention of metastasis and the development of novel treatments for metastatic cancer are urgent challenges, the molecules contributing to BC metastasis and prognosis remain largely unknown. This study aimed to identify and analyze novel therapeutic target molecules for metastatic BC.

Materials and methods

We collected gene expression datasets for BC cell lines from Gene Expression Omnibus and selected genes highly expressed in

SUBMITTER: Arai O 

PROVIDER: S-EPMC12631170 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature