Neutrophil gene expression in COVID-19 patients with acute respiratory distress syndrome.

ABSTRACT:

Background

Although an increase in neutrophil count has been observed in patients with coronavirus disease 2019 (COVID-19), the relationship between the systemic neutrophil transcriptome and clinical course of COVID-19 remains unclear. Hence, we examined the relationship between the clinical course and RNA sequencing analysis results in COVID-19 patients.

Methods

Peripheral blood samples were obtained from 28 patients with COVID-19-associated ARDS and 16 healthy controls. Bulk RNA sequencing was performed, and clustering analysis was used to explore relationships between gene expression and clinical characteristics. In a separate cohort, neutrophils were isolated from the peripheral blood of five COVID-19 patients with ARDS for single-cell RNA sequencing to further character

SUBMITTER: Ito H 

PROVIDER: S-EPMC12631193 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature