Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus.

ABSTRACT:

Aim

The role of somatostatin (SST) in the modulation of cholinergic neurotransmission has not been explored previously in human bronchi. We investigated the effects of SST, selective agonists of the five SST receptors SSTR, and octreotide (a SSTR_2,3,5 agonist) on the cholinergic contraction induced in vitro either by acetylcholine or by electrical field stimulation (EFS) in human bronchial rings.

Methods

Human bronchial rings (n = 326) were obtained from 32 patients undergoing surgery for lung carcinoma. 5 Hz EFS (biphasic pulse width: 1 ms; constant current: 320 mA for 10 s) induced contractions that reached about ∼30% of the maximum contraction caused by 40 Hz EFS. Bronchial rings were stimulated for 240 min in the presence or absence of various concentra

SUBMITTER: Brollo M 

PROVIDER: S-EPMC12631201 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature