Epigenetic regulation of <i>SYNGAP1</i> in alcohol use disorder in whole blood and saliva.

ABSTRACT: Epigenetic regulation is significantly altered in individuals with alcohol use disorder (AUD), representing a promising avenue for understanding its pathomechanisms and developing new therapies. In an earlier epigenome-wide study of CD3+ T cells, we identified SYNGAP1-a critical regulator of synaptic plasticity that influences neuronal communication and network remodeling-as epigenetically dysregulated, with significantly lower DNA methylation (DNAm) in patients than controls. After three weeks of inpatient withdrawal, SYNGAP1 DNAm increased to control levels. In the present study, we aimed to validate these differential SYNGAP1 DNAm levels in an independent cohort of 64 AUD patients and 83 healthy controls in peripheral blood and saliva, to assess its potential as a b

SUBMITTER: Edelmann S 

PROVIDER: S-EPMC12631263 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature