Enterocyte Culture on a Hybrid Transwell-Inserted Gut-on-a-Chip for Liquid-Liquid and Air-Liquid Interface Conditions.

ABSTRACT: Intestinal models have been studied extensively using in vitro microfluidic platforms, often called gut-on-a-chip devices, which replicate the physiological environment and functions of the human intestine. The role of fabrication techniques in developing these microfluidic systems is increasingly significant. Photolithography has traditionally been used for microchannel preparation, oxygen-plasma surface treatment, and conventional bonding methods that attach microchannels to surfaces. However, photolithography is limited to perfectly flat surfaces, is costly, requires specialized equipment, and must be conducted in controlled environments free from contaminants, making the process slow and labor-intensive. Consequently, there is a need for a fabrication method that enables rapid p

SUBMITTER: Charoensri T 

PROVIDER: S-EPMC12631310 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature