Aqueous Humor Proteome in RVO-Associated Macular Edema: Analysis during Three Consecutive Conbercept Treatments.

ABSTRACT:

Purpose

This exploratory study aimed to assess the aqueous humor (AH) proteome in patients with retinal vein occlusion (RVO) and macular edema (ME) receiving three consecutive intravitreal injections of Conbercept, to identify potential molecular pathways, and to generate hypotheses.

Methods

Label-free quantitative liquid chromatography-tandem mass spectrometry was applied to analyze the AH of patients with RVO and ME who underwent three consecutive Conbercept intravitreal injections (IVI) and age-matched controls. The alterations in BCVA, central retinal thickness (CRT), and AH proteins were ascertained through a permutation-based calculation (the false discovery rate was set at 0.05). A repeated-measures analysis determined the most significantly changed protein in the AH

SUBMITTER: Liu S 

PROVIDER: S-EPMC12631356 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature