Binary Polymeric System Based on Fish Collagen and Poloxamer 407: Mechanical and Rheological Analysis for Pharmaceutical and Biomedical Applications.

ABSTRACT: Tilapia skin collagen is recognized for its regenerative properties and biocompatibility. Poloxamer 407 (P407) is a copolymer considerate ideal for stabilization and emulsification. The objective of this study was to develop a binary polymer system composed of tilapia skin collagen and P407, seeking to optimize its properties for pharmaceutical and biomedical applications. Using the two-block Box-Behnken 3³ factorial design, the mechanical and rheological analysis of the binary polymer systems was evaluated, varying the temperature, polymer concentration and the combination of components. The binary polymer systems demonstrated pseudoplastic behavior (shear thinning). The results indicate that the combination of tilapia collagen with P407 provides synergistic behavior, promoting

SUBMITTER: Uchida DT 

PROVIDER: S-EPMC12631358 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature