Synergistic Noncovalent Interaction Drives High-Performance Fluorescence Detection of Drug Analogs.

ABSTRACT: Accurate and sensitive detection of illicit drugs, including methamphetamine (MA), is essential for maintaining public health and security. Stringent regulatory controls on MA have driven the adoption of N-methylphenethylamine (MPEA) as a prevalent experimental surrogate in scientific research. While fluorescence-based sensing demonstrates efficacy in detecting MPEA, its practical application remains constrained by selectivity and sensitivity. To overcome these limitations, we engineered a fluorescence sensing strategy based on synergistic noncovalent interaction and employed AgPDT (PDT = 4-pyridinethiol) as a recognition motif enabling both exceptional selectivity (F ₀/F shows a 450% enhancement versus structural analogs) and remarkable sensitivity (LOD = 1

SUBMITTER: Yu J 

PROVIDER: S-EPMC12631389 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature