Developmental and adult expression of the Meis2 transcription factor in the central nervous system of <i>Xenopus laevis</i>: a developmental and evolutive analysis.

ABSTRACT: Myeloid ecotropic viral integration site 2 (Meis2) is a three-amino-acid-loop-extension (TALE) transcription factor (TF) involved in key neurodevelopmental processes, such as neuronal differentiation and brain regionalization. Its expression is well documented in amniotes and teleosts, but its distribution in the developing brain of anamniote tetrapods remains poorly understood. Therefore, the distribution of Meis2-immunoreactive (-ir) cells was analyzed throughout the developmental stages of the Xenopus laevis brain, revealing a dynamic, stage-specific expression pattern. From the early embryonic stages, Meis2-ir cells were found in the telencephalon, specifically in the ventrolateral pallium and subpallium; the diencephalon, particularly in the prosomere 3 and transiently in p2 an

SUBMITTER: Morona R 

PROVIDER: S-EPMC12631407 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature