Radiomic signatures from postprocedural MRI thalamotomy lesion can predict long-term clinical outcome in patients with tremor after MRgFUS: a pilot study.

ABSTRACT:

Objective

Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an effective treatment for essential tremor (ET) and tremor-dominant Parkinson's disease (PD), yet a substantial proportion of patients experience tremor recurrence over time. Reliable imaging biomarkers to predict long-term outcomes are lacking. The purpose of the study was to evaluate whether radiomic features extracted from 24-h post-treatment MRI can predict clinically relevant tremor recurrence at 12 months after MRgFUS thalamotomy, using a machine learning (ML) approach.

Materials and methods

Retrospective, single-center study included 120 patients (61 ET, 59 PD) treated with unilateral MRgFUS Vim thalamotomy between February 2018 and June 2023. Tremor severity was assessed using part A of t

SUBMITTER: Innocenzi A 

PROVIDER: S-EPMC12631418 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature