Stability of G/C DNA Tetraplexes at Physiological pH Formed at the Promoter-UTR Intersection of the <i>RAP2C</i> Gene: Structural Multitude of a G/C Rich Genomic Segment.

ABSTRACT: Genomic guanine-rich segments are prone to adopting self-associated noncanonical structures termed G-quadruplex structures. An overabundance of reports reveals their existence prevalently at important genomic locations, including oncogenic promoters, exonic regions, immunoglobulin switch regions, telomeres, etc. Undeniably, these structures have been the subject of curiosity for many decades, leading to mounting evidence suggestive of their involvement in key cellular processes. Herein, we identified a 45-mer G-rich segment containing G5 tracts, present at the intersection of the promoter and 5'-UTR region of the RAP2C gene of the ras oncogene family, found to fold into a G-quadruplex structure. We employed biochemical and biophysical techniques for structural characterizatio

SUBMITTER: Singh A 

PROVIDER: S-EPMC12631430 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature