Physical Activity Over the Adult Life Course and Risk of Dementia in the Framingham Heart Study.

ABSTRACT:

Importance

Being physically active is protective against dementia. Yet, it is unknown when during the adult life course physical activity is most associated with dementia risk.

Objective

To determine whether higher physical activity levels in early adult life, midlife, or late life are associated with lower risk of all-cause or Alzheimer disease (AD) dementia.

Design, setting, and participants

This prospective cohort study used data from the Framingham Heart Study Offspring cohort. The offspring of participants in the original Framingham Heart Study cohort who were dementia free and had physical activity measured at baseline (early adult life [1979-1983], midlife [1987-1991], or late life [1998-2001]) were followed up for a mean (SD) of 37.2 (7.1), 25.9 (8.5), or 14.5

SUBMITTER: Marino FR 

PROVIDER: S-EPMC12631490 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature