Inflammation, glucose metabolism, and nutritional markers in relation to all-cause and cardiac mortality among initial hemodialysis patients: a multicenter cohort study.

ABSTRACT:

Objective

To investigate the prognostic value of inflammatory biomarkers including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), glucose metabolism (glucose-to-lymphocyte ratio, GLR), and nutritional (albumin, ALB) biomarkers for predicting all-cause and cardiac mortality in patients initiating hemodialysis (HD), and evaluates their incremental value when integrated into traditional risk models.

Methods

A retrospective cohort of 795 initial HD patients (2014-2020) was analyzed, with follow-up through 2022. Cox proportional hazards models were used to assess associations between biomarkers and mortality. Predictive performance was evaluated using time-dependent ROC curves, C-index, net reclassification improv

SUBMITTER: Hou SM 

PROVIDER: S-EPMC12631612 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature