Efgartigimod non-responders after the first treatment cycle in generalized myasthenia gravis: a retrospective analysis of predictive factors.

ABSTRACT:

Objective

This study aimed to identify predictors of suboptimal response to efgartigimod in patients with generalized myasthenia gravis (gMG).

Methods

In this single-center retrospective study, 35 gMG patients treated with efgartigimod were categorized into responders (n = 25) and non-responders (n = 10). Responders were defined by a reduction of >2 points in MG-ADL or >3 points in QMG score after one cycle, whereas non-responders showed improvement below these thresholds and subsequently responded to eculizumab. Demographic, clinical, and serological features were compared using univariate and multivariate analyses.

Results

Non-responders had higher baseline gross motor and respiratory sub-scores. Univariate analysis revealed that thymoma, non-thymoma t

SUBMITTER: Niu Z 

PROVIDER: S-EPMC12631618 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature