Serum ferritin and admission stroke severity in first-ever acute ischemic stroke: a cross-sectional study.

ABSTRACT:

Background

Iron dysregulation may aggravate ischemic brain injury through oxidative stress and ferroptosis. Serum ferritin (SF) reflects iron storage and inflammation, but its relationship with initial neurological deficit in first-ever acute ischemic stroke (AIS) remains unclear.

Objective

To investigate the association between admission SF levels and stroke severity in patients with first-ever anterior circulation AIS.

Methods

This cross-sectional study included 288 patients with first-ever anterior circulation AIS admitted within 72 h of onset. SF was measured within 24 h of admission. Stroke severity was assessed using the NIHSS; greater neurological deficit was defined as NIHSS > 5. Multivariable logistic regression, sensitivity analyses, and restricted cubic spl

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12631621 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature