Accelerated biological aging based on DNA methylation clocks is a predictor of stroke occurrence: a systematic review and meta-analysis.

ABSTRACT:

Background

Although traditional vascular risk factors, such as hypertension and diabetes, are incorporated into stroke risk prediction models, a significant proportion of stroke events remain unexplained by these models. Increasing evidence suggests that accelerated biological aging, as measured by DNA methylation clocks, may reflect reduced organ function and heightened susceptibility to disease. However, the relationship between epigenetic age acceleration (EAA) and stroke risk remains poorly understood, with limited comprehensive synthesis of the available evidence.

Methods

We conducted a systematic search of PubMed, Embase, Web of Science, and Cochrane Library databases (up to January 10, 2025) for observational studies examining the relationship between DNA methylation-

SUBMITTER: Feng J 

PROVIDER: S-EPMC12631622 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature