Microfluidic All-Solid-State Electrodes for Real-Time Monitoring of Salivary Cations (Na⁺, K⁺, and Ca² ⁺).

ABSTRACT: Saliva is a valuable biofluid for noninvasive diagnostics, offering insights into oral and systemic health through ion composition analysis. Key electrolytes such as calcium (Ca^{2 +}), sodium (Na⁺), and potassium (K⁺) are critical for tooth enamel integrity, remineralization, and caries resistance. Conventional detection methods such as atomic absorption spectroscopy (AAS) and inductively coupled plasma mass spectrometry (ICP-MS) are impractical for real-time or point-of-care applications. Here, we report the fabrication and integration of all-solid-state ion-selective electrodes (ISEs) into a microfluidic flow device for real-time, low-volume, and wireless salivary ion monitoring. The platform enables precise fluid handling, automated processing,

SUBMITTER: Ozeki Y 

PROVIDER: S-EPMC12631687 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature