Engineered Cyclodextrin-Starch Hydrogels for pH-Triggered Drug Release.

ABSTRACT: Oral drug delivery systems must ensure that therapeutic agents reach the target site, minimizing premature release in the gastric environment. In this context, hydrogels have emerged as promising biomaterials due to their ability to swell, retain, and release drugs in response to environmental stimuli. However, optimizing hydrogel formulations, considering both the properties and the polymer-drug interactions, is challenging. Herein, starch and β-cyclodextrin (βCD) were modified with GMA to introduce polymerizable vinyl groups. The βCD was modified by transesterification, while the starch produced three distinct isomers due to additional epoxide ring-opening reactions. The modified molecules were cross-linked via free radical polymerization. A simplex-centroid design optimized the hydrogel

SUBMITTER: Reis AC 

PROVIDER: S-EPMC12631703 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature