Paper Matters: Technical Evaluation of Paper-Based Substrates for Enhanced Preconcentration of Biomolecules in Liquid Biopsy Diagnostics.

ABSTRACT: Early detection of disease biomarkers remains a major challenge due to their low abundance in biological fluids. Preconcentration strategies can address this issue, but conventional approaches often require additional time, costly materials, or complex instrumentation. This work explores the use of paper-based substrates as a sustainable and cost-effective alternative for analyte preconcentration, highlighting how the choice of paper type critically influences sensitivity enhancement in analytical methods without compromising simplicity. Three cellulose-based papers (Whatman grade 1, Whatman grade 4, and a commercial laboratory filter paper) were systematically characterized and configured as 3D-origami-inspired, capillary-driven platforms. Their structural and fluidic properties were eval

SUBMITTER: Kalligosfyri PM 

PROVIDER: S-EPMC12631723 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature