ZC3H12D and DDX5 Antagonistically Regulate Cyclin D1 mRNA Stability and Cell Cycle Progression in Breast Cancer.

ABSTRACT:

Background

An imbalance between the expression of cell cycle-promoting and cell cycle-inhibiting genes triggers uncontrolled cell cycle progression in cancer cells. However, the mechanism controlling the expression of cell cycle-related genes, especially those whose expression is mediated by RNA-binding proteins (RBPs), remains elusive.

Methods

All RBP expression in human breast cancer was analyzed by bioinformatic methods. The expression and prognostic value of RBPs ZC3H12D (zinc finger CCCH domain-containing protein 12D) and DDX5 (DEAD box protein 5) in breast cancer were analyzed in public databases and tumor samples. The functions of ZC3H12D and DDX5 in breast tumor cell cycle regulation and tumor progression were determined in vitro and in vivo. RNA sequencing, infrared

SUBMITTER: Sun L 

PROVIDER: S-EPMC12631744 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature