Reference values and biological factors influencing skin autofluorescence.

ABSTRACT:

Introduction

Tissue glycation, measured as skin autofluorescence (SAF) with an AGE Reader, has been associated with incident type 2 diabetes (T2D), cardiovascular disease (CVD), and CVD and cancer mortality. Validated reference intervals in healthy individuals are needed to make useful and precise risk estimations.

Methodology

This study utilises data from 82,870 participants of Western European descent in the Lifelines Cohort Study, a population-based study in the Netherlands. Reference values for SAF were established in healthy participants. Decade-specific mean SAF values were evaluated for former and current smokers, T2D, CVD, and impaired renal function. We also assessed the association of regular physical activity (PA) with SAF scores.

Results

Reference values f

SUBMITTER: Wolffenbuttel BHR 

PROVIDER: S-EPMC12631760 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature