High Burden of Coinfections With Epidemic-Prone Pathogens Among Febrile Patients in Nigeria: A Multi-Pathogen Surveillance Study.

ABSTRACT:

Background

Characterizing the etiology of acute febrile illness (AFI) remains a critical public health priority in malaria-endemic regions such as Nigeria, where constrained diagnostic capacity frequently contributes to misdiagnosis and delays in outbreak detection and response. This study aimed to explore the burden and nature of pathogen coinfections among febrile patients and to assess whether coinfection patterns were associated with clinical or epidemiologic differences.

Methods

Patients presenting with AFI at tertiary hospitals in north-central and southern Nigeria were screened for 25 pathogens using the TaqMan Array Card multi-pathogen polymerase chain reaction. Enrollment was conducted over a 12-month period at each site, August 2023 to September 2024. The analysis

SUBMITTER: Erameh C 

PROVIDER: S-EPMC12631764 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature