Pharmacological and non-pharmacological treatments for refractory paediatric Still's disease: a scoping review.

ABSTRACT:

Objectives

Management of systemic juvenile idiopathic arthritis, or Still's disease, has been transformed by the introduction of IL-1 and IL-6 antagonists. Despite this, a minority have refractory disease with three subtypes described: (1) persistent arthritis, (2) recurrent or difficult-to-treat macrophage activation syndrome (MAS), or (3) interstitial lung disease. This scoping review aimed to summarize available evidence for the treatment of refractory paediatric Still's.

Methods

Databases were searched using terms 'systemic JIA' or 'Still's disease' AND 'refractory', plus synonyms. Records were screened for papers on the treatment of refractory Still's, before reviewing full texts. Controlled trials, uncontrolled trials and case series/reports involving patients with dis

SUBMITTER: Twynam-Perkins E 

PROVIDER: S-EPMC12631771 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature