Implementation of a Bundle for the Management of Patients With Gram-Negative Bloodstream Infection: A Pre-Post Quasi-experimental Study.

ABSTRACT:

Background

Lack of international guidelines for gram-negative bloodstream infection (GN-BSI) management poses clinical challenges. We aimed to assess whether implementing a management bundle for patients with GN-BSI affected mortality and/or emergence of multidrug resistance (MDR).

Methods

This was a single-center, quasi-experimental study including adult patients hospitalized with monomicrobial GN-BSI. In the preimplementation phase ("pre-phase," 2018-2019), no standardized protocol was used. In the postimplementation phase ("post-phase," 2022-2023), a bundle was applied including predefined rules for follow-up blood cultures (FU-BCs), imaging, β-lactam administration schedule, and treatment duration. Primary endpoint was 30-day all-cause mortality; secondary endpoint was 3

SUBMITTER: Bonazzetti C 

PROVIDER: S-EPMC12631777 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature