Descriptive Epidemiology of Acute Febrile Illness Patients in Nigeria: Pathogens of Global Public Health Significance Detected Using a Multi-Pathogen Detection Tool.

ABSTRACT:

Background

Undifferentiated acute febrile illness (AFI) is a diagnosis that elicits public health concern, as it may be the result of an undiagnosed case of a pathogen of epidemic potential. This study compares the hospital-based incidence and distribution of AFI-causing pathogens in Nigeria, utilizing polymerase chain reaction (PCR)-based surveillance.

Methods

Patients presenting with AFI at tertiary hospitals in Federal Capital Territory (north-central) and Edo (south) were enrolled from August 2023 to September 2024. Patients were screened for 25 pathogens using the TaqMan Array Card multi-pathogen PCR. The analysis compared the occurrence and distribution of pathogens, alongside environmental and demographic factors.

Results

One thousand two hundred febrile patien

SUBMITTER: Courtney LP 

PROVIDER: S-EPMC12631784 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature