Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration.

ABSTRACT: Periodontitis is a multifactorial inflammatory disease involving pathogenic biofilm formation, amplified oxidative stress, and impaired tissue regeneration. In addition to its complicated pathology, effective treatment of periodontitis is challenged by a dynamic oral microenvironment that prevents drug retention. To overcome these issues, an anti-bacterial, ROS-scavenging, and tissue-regenerative hydrogel system (HQUP@TF127) is developed. In this triple-functional HQUP@TF127, a ROS-responsive gatekeeper on hollow mesoporous silica nanoparticles enabled the spatiotemporally controlled release of quercetin, a naturally occurring anti-inflammatory and osteogenic ingredient. The covalent attachment of the antibacterial, 4-terpineol with thermosensitive Pluronic F127 prolonged retention time, t

SUBMITTER: Wang G 

PROVIDER: S-EPMC12631824 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature