Lactate-Modulating Nanoreactors Facilitate Self-Amplifying Pyroptosis and the cGAS-STING Cascade for Potentiated Catalytic-Immunotherapy.

ABSTRACT: The strategic induction of pyroptosis, coupled with the targeted potentiation of cGAS-STING activation, represents a promising immunostimulatory approach. Herein, an intelligent lactate-depleting LOCoF₂ nanoreactor system is developed that orchestrated self-amplifying pyroptosis induction and cGAS-STING signaling potentiation for enhanced catalytic immunotherapy. This nanoplatform integrated cobalt fluoride (CoF₂) nanoparticles with lactate oxidase (LOx), endowing it with dual enzymatic capabilities. Therefore, the LOCoF₂ nanoreactor initially served as a pyroptosis activator, synergistically inducing pyroptosis in cancer cells by catalyzing the sequential generation of reactive oxygen species (ROS) while simultaneously inhibiting damage repair mechanisms.

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12631825 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature