Physiological pH Transition-Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles.

ABSTRACT: Protein corona alters the biological identities and interactions of nanoparticles with cells, needing to be thoroughly scrutinized before in vivo applications. Importantly, protein corona is evolving as nanoparticles cross different microenvironments, leading to unpredictable biological behaviors. Unveiling how physiological conditions change, especially pH changes associated with tumor-targeted delivery, affect protein corona composition and subsequent bio-interactions, is thus essential for understanding the bio-fate and therapeutic efficacy of nanomedicines. This study investigates how physiological pH transitions influence protein corona dynamics on silica nanoparticles, cellular uptake, and inflammatory responses. Incubating nanoparticle-protein corona complexes at different pH values

SUBMITTER: Ge Y 

PROVIDER: S-EPMC12631826 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature