Conductive Microneedles Loaded With Polyphenol-Engineered Exosomes Reshape Diabetic Neurovascular Niches for Chronic Wound Healing.

ABSTRACT: Diabetic wound healing remains a major clinical challenge due to the accumulation of advanced glycation end products (AGEs), reactive oxygen species (ROS), and proinflammatory cytokines under hyperglycemic conditions, which collectively impair neurovascular regeneration. Here, a biological-electrical therapeutic platform is reported by synergizing polyphenol-engineered Saccharina japonica exosomes (CA@Exos)-derived biological signals with electroconductive microneedles (pCNTs-ASA MNs)-delivered electrical cues, achieving a dual-pathway to reshape neurovascular niches during the diabetic wound healing process. CA@Exos serve as bioactive cargo to suppress AGE formation, scavenge ROS, and reverse the inflammatory microenvironment, while their intrinsic bioactivities in modulating angiogenesis

SUBMITTER: Liu D 

PROVIDER: S-EPMC12631848 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature