Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP-Mediated Mechanosensitization of Intestinal Epithelial Cells.

ABSTRACT: Intestinal fistula is a serious condition characterized by abnormal connections between the intestine and surrounding tissues. Despite advances in comprehensive management of intestinal fistulas, patients often need to undergo definitive surgery and face life-threatening complications due to ineffective closure measures. Herein, a mechanically active hydrogel (GNGP) that actively constricts intestinal fistulas in response to body temperature is presented. It possesses broad-spectrum antimicrobial properties, excellent adhesion, suitable degradation properties, and a balance between injectable properties and mechanical activity-which, together, enable the in situ sealing of intestinal fistulas. Moreover, GNGP hydrogel accelerates the re-epithelialization process of rabbit intestinal fistula

SUBMITTER: Li Z 

PROVIDER: S-EPMC12631856 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature