A Novel Self-Regulated, Non-Directional Magnetic Thermos-Brachytherapy ¹²⁵I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape.

ABSTRACT: Integrating mild hyperthermia (MH) with ¹²⁵I brachytherapy holds potential for overcoming treatment resistance and improving anticancer efficacy. Here, magnetic nanoparticles (MNPs) with a suitable Curie temperature are constructed and incorporated with silver rods coated with ¹²⁵I to form composite seeds. In vitro simulations and in vivo validations demonstrated their effective performance in radiation dose and temperature control. Compared with traditional thermoseeds and previously reported MNPs, this composite seed exhibits direction-independent and self-regulated heating efficiency. Additionally, the titanium shell prevented MNPs leakage and enabled its repeated hyperthermia treatment capacity. Subsequently, the enhanced pancancer anticancer efficacy of the compo

SUBMITTER: Xu B 

PROVIDER: S-EPMC12631875 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature