Single-Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Muller Cell Autophagy Through PI3K/AKT Signaling Following MCAO-Induced Retinal Ischemia.

ABSTRACT: Central retinal artery occlusion (CRAO) can lead to retinal ischemia (RI), resulting in painless vision impairment. Müller cells, the principal supporting glial cells of the retina, are distributed throughout its layers and play pivotal roles in maintaining retinal homeostasis by regulating inflammation, oxidative stress, and angiogenesis following RI. However, the specific role of Müller cells in RI induced by middle cerebral artery occlusion (MCAO) remains unclear. In this study, single-nucleus RNA sequencing is employed to investigate transcriptional changes in various retinal cell types following MCAO-induced RI. A novel Müller cell subpopulation, characterized by the highest expression of the high-mobility group A2 gene (Hmga2), emerged after RI. Knockout of Hmga2 alleviated neuroinfl

SUBMITTER: Lv W 

PROVIDER: S-EPMC12631878 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature