A Lipid with Lewis Pair-Mediated Targeting and Multiple Stimuli-Responsive Delivery of Antibiotics for Bacterial Infections.

ABSTRACT: Integrating both targeted delivery and stimulus-responsive release into a single small molecule for drug delivery presents challenges related to synthesis, stability, and efficacy. In this study, single-molecular lipids incorporating a Lewis pair (Lp-lipids) are described, composed of a Lewis acid (phenylboronic acid) and a Lewis base (amine) within a single small molecular structure, to formulate lipid nanoparticles for antibiotic delivery. For targeted delivery to bacterial biofilms, the phenylboronic acid selectively binds to bacteria or biofilms by forming boronate ester bonds with diols in the microbial dextran or peptidoglycan. Additionally, the amine group responds to the acidic microenvironment, enhancing electrostatic interactions with bacteria and biofilms. Regarding stimulus-res

SUBMITTER: Yan X 

PROVIDER: S-EPMC12631898 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature