T2T Genomes Unveil Centromere Architecture and Adaptive Divergence in Large Yellow Croaker (Larimichthys crocea).

ABSTRACT: The large yellow croaker (Larimichthys crocea) is a key aquaculture species, yet gaps in high-quality genomes hinder studies of centromeric and adaptive evolution. This study presents two telomere-to-telomere (T2T), gapless genomes from the Min-Yuedong (MYD) and Daiqu (DQ) populations, which diverged 4.18 million years ago. The centromeres are characterized by a 42 bp tandem repeat (Cen-42) and invasions by endogenous retrovirus 1 (ERV1) of long terminal repeat (LTR) elements. Both populations exhibit transcriptional activity in centromeric regions, but display significant divergence in gene number and composition, likely driven by rapid population expansion and selective pressure. In addition, 5S ribosomal RNA genes form ultra-large tandem repeat clusters in the short-arm regions of more

SUBMITTER: Cui Y 

PROVIDER: S-EPMC12631908 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature