A Multifunctional Molecular Probe for Multimodal Imaging-Guided Potent Photothermal/Photodynamic Therapy of Endometriosis.

ABSTRACT: Multifunctional small-molecule theranostic agents hold significant clinical potential for non-invasive endometriosis (EMS) management. Current EMS treatment faces challenges due to imprecise lesion localization and therapy-associated side effects. Herein, an integrated theranostic probe, cRGDyK-ICG-Lys-DTPA@Gd (cRGD-ILD), designed for concurrent precise lesion localization and targeted phototherapy in EMS, is developed. This molecular probe integrates three key functional components: the DTPA@Gd complex provides contrast for magnetic resonance imaging, the ICG fragment enables fluorescence imaging and photoacoustic imaging while serving as the phototherapeutic agent, and the cRGD peptide targets integrin α_vβ₃ receptors to facilitate precise accumulation in ectopic end

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC12631912 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature