Delayed postoperative hemorrhage (DEPOH) in an Irish Wolfhound with the <i>SERPINF2</i> c.605 T/T genotype: case description and variant prevalence across dog breeds.

ABSTRACT:

Introduction

Delayed postoperative hemorrhage (DEPOH) is a life-threatening complication of major surgical procedures in Greyhounds affecting up to 26-30% of dogs. DEPOH has also been reported in Scottish Deerhounds, but it is unclear whether any other breeds are affected. A genetic variant (c.605 C > T) was recently discovered in the SERPINF2 gene that is currently used as a biomarker for increased risk of DEPOH. The objective of this study was to provide the first report of DEPOH occurring in association with the SERPINF2 variant in an Irish Wolfhound. SERPINF2 variant prevalence was also surveyed across dog breeds to identify other breeds that may be at increased risk for DEPOH.

Methods

Case history and medical records from the affected dog were revie

SUBMITTER: Court MH 

PROVIDER: S-EPMC12631970 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature