Development and validation of a nomogram for identifying cognitive impairment in patients with leukoaraiosis.

ABSTRACT:

Background

Leukoaraiosis (LA) is a common cerebral small vessel disease in elderly populations that frequently leads to cognitive impairment and may progress to vascular dementia. Early identification of cognitive dysfunction remains challenging due to the subtle onset and lack of specific biomarkers.

Objective

To identify key factors associated with cognitive impairment in LA patients and develop a logistic regression-based identification model to facilitate early clinical recognition and intervention.

Methods

This retrospective cross-sectional study included 390 LA patients admitted to the Department of Neurology between June 2020 and April 2023. Patients were classified into cognitive impairment (CI) and non-cognitive impairment (NCI) groups based on Montreal Cogni

SUBMITTER: Zhang G 

PROVIDER: S-EPMC12631993 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature