Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis.

ABSTRACT:

Background

Noradrenaline is currently the first-line vasopressor in treatment of circulatory failure. Its dose reflects illness severity, and together with dopamine, dobutamine and adrenaline, it is used in the Sequential Organ Failure Assessment (SOFA) score to grade cardiovascular dysfunction. Over the years, noradrenaline use has increased and it has largely replaced dopamine. As part of the SOFA-2 update, we conducted a systematic review and dose-response meta-analysis to assess the association between noradrenaline dose and mortality.

Methods

We searched MEDLINE, Embase, and Web of Science from 1 January 2013 to 30 October 2024 for studies reporting mortality by noradrenaline dose in critically ill adults. The primary outcome was mortality. We generated pooled relative

SUBMITTER: Reinikainen M 

PROVIDER: S-EPMC12632045 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature