Prevotella copri alleviates diarrhea in weaning piglets through gut microbiota modulation and arachidonic acid-AHR-NRF2 pathway activation.

ABSTRACT:

Background

Diarrhea remains a major health concern in both young animals and humans. Prevotella spp., a dominant commensal genus in the healthy porcine gut, becomes increasingly abundant following weaning, suggesting a potential role during this critical transitional period. However, its involvement in post-weaning diarrhea remains poorly understood. Here, we aim to elucidate the role and underlying mechanisms of Prevotella in alleviating diarrhea in weaned piglets.

Results

To model unsanitary housing conditions, piglets were housed in uncleaned pens containing residual fecal matter from previous occupants and exposed to cold stress by maintaining the ambient temperature at 19 °C, below the optimal 28 °C. Under these conditions, piglets were orally administered either a blan

SUBMITTER: Lan C 

PROVIDER: S-EPMC12632048 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature