Total bilirubin as a mortality predictor in non-elderly hemodialysis patients: a multicenter retrospective cohort study.

ABSTRACT:

Background

The association between serum total bilirubin (TBIL) levels and mortality in maintenance hemodialysis (MHD) patients, especially when stratified by age, has not been clearly established.

Methods

We performed a multicenter retrospective analysis of 409 MHD patients (40 deaths, 9.8%) over a median follow-up of 31.3 months (interquartile range (IQR), 28.9-31.8). Cox regression models evaluated TBIL's predictive role for mortality. Receiver operating characteristic (ROC) curve-derived cutoff (8.79 µmol/L) stratified patients into high (H, TBIL > 8.79 µmol/L, n = 236) and low (L, TBIL ≤ 8.79 µmol/L, n = 173) groups. Multivariable Cox models adjusted for demographics, comorbidities (Model 2), and laboratory markers (Model 3). Additionally, to mitigate overfitting and as

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12632052 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature