Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis.

ABSTRACT: Sarcopenia, a prevalent age-related degenerative disorder, poses significant challenges in geriatric care. Chinese leek demonstrates therapeutic potential against sarcopenia progression, with emerging evidence suggesting its extracellular vesicles (EVs) may mediate these effects. Notably, plant-derived EVs have garnered increasing attention due to their low immunogenicity and capacity for cross-kingdom molecular delivery. This study investigates Chinese leek-derived EVs (CL-EVs) as novel regulators of muscle homeostasis through multi-omics approaches. CL-EVs were isolated via differential ultracentrifugation and characterized using nanoparticle tracking analysis, TEM, and proteomic profiling. Using a dexamethasone (DEX)-induced C2C12 myotube atrophy model, we demonstrated CL-EVs' cellular

SUBMITTER: Qi W 

PROVIDER: S-EPMC12632053 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature