Prognostic value of antepartum LDH serum levels in predicting adverse maternal outcomes in hypertensive disorders of pregnancy: a prospective cohort study.

ABSTRACT:

Background

Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal mortality, particularly in low-resource settings. While lactate dehydrogenase (LDH) has been proposed as a prognostic biomarker, its clinical utility is limited by a lack of consensus on a standardized threshold for interpretation. This study aimed to evaluate the predictive performance of antenatal LDH for adverse maternal outcomes and establish a clinically applicable cutoff for risk stratification.

Methods

This prospective cohort study included 336 pregnant women with HDP admitted to a national tertiary referral hospital in Vietnam. Serum LDH levels were measured before delivery, and treating clinicians were blinded to the results to prevent performance bias. The primary outcome was a com

SUBMITTER: Thang NM 

PROVIDER: S-EPMC12632058 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature