Threshold effect of systemic immune-response index on in-stent neoatherosclerosis among patients with drug-eluting stent restenosis.

ABSTRACT:

Background

In-stent neoatherosclerosis (ISNA) is a key mechanism underlying drug-eluting stent in-stent restenosis (DES-ISR), with inflammation playing a critical role. This study aimed to assess the association between the systemic immune-response index (SIRI) and ISNA in DES-ISR patients.

Methods

A retrospective analysis included 212 patients with DES-ISR who underwent coronary angiography and optical coherence tomography (OCT) at least 12 months after stent implantation. SIRI was calculated as (neutrophil count × monocyte count)/lymphocyte count and divided into tertiles. Multivariate logistic regression, smooth curve fitting, threshold effect, and subgroup analyses were performed to evaluate the relationship between SIRI and ISNA risk.

Results

Higher SIRI tertiles

SUBMITTER: Yang S 

PROVIDER: S-EPMC12632093 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature