A unified catalog of 14,062 microbial species reference genomes provides new insight into the gut microbiota in high-altitude mammals.

ABSTRACT:

Background

The gut microbiota is essential for host health and survival. The understanding of the diversity, stability, and functional traits of mammalian gut microbiota, as well as the evolutionary patterns of the host-gut microbiota holobiont in non-human mammals remains limited. Here, we conducted a comprehensive analysis of the gut microbiota in non-human mammals.

Result

We used 1,412 samples from large herbivores living in the Qinghai-Tibetan Plateau (QTP), recovered 14,062 high-confidence species-level genome bins (SGBs), of which more than 88% represent potentially novel species. We found that recurring lineage-specific bacterial gain-loss events along the host phylogeny might drive the shaping of the gut microbiota in these QTP mammals. Functional characteristics of

SUBMITTER: Li X 

PROVIDER: S-EPMC12632101 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature