CLOCK-mediated acetylation of NF-κB p65 drives immune evasion in breast cancer.

ABSTRACT:

Background

Disruption of circadian rhythm (DCR) has been connected with breast cancer (BC) susceptibility; whereas it is unclear whether status of key clock genes could be used in predicting BC prognosis, tumor immune microenvironment, and immunotherapy responses.

Results

Circadian clock genes demonstrate significant dysregulation in BC, where elevated CLOCK expression emerges as an independent prognostic factor strongly correlated with adverse clinical outcomes. CLOCK-overexpressing BC cells exhibit enhanced proliferative ability and strong resistance to chemotherapy drugs doxorubicin and gemcitabine. High CLOCK expression correlates with reduced CD8⁺ T cell infiltration and increased M2 macrophage polarization, consistent with increased immune checkpoint molecul

SUBMITTER: Quan X 

PROVIDER: S-EPMC12632107 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature