Internally Self-Assembled Pickering Mesosomes Stabilized by Positively Charged Lactoferrin.

ABSTRACT: Mesosomes as sub-micrometer-sized emulsions containing internally self-assembled lyotropic liquid crystalline (LLC) mesophases were engineered using lactoferrin (LF) as a Pickering stabilizer. LF was pretreated with ultrasonication to prevent agglomeration and applied under controlled pH conditions during processing, resulting in emulsions with a positive surface charge and high stability. Glycerol monooleate (GMO) in mixtures with oleic acid (OA) at varying concentration ratios were used to produce four different lyotropic mesophases: bicontinuous cubic (Pn3m), inverse hexagonal (H₂), inverse micellar cubic (Fd3m), and microemulsions (ME). At a preadjusted pH of 4, LF stabilized all four lyotropic mesophases via a Pickering-type mechanism, forming me

SUBMITTER: Li Y 

PROVIDER: S-EPMC12632182 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature