Paraventricular nucleus neurons: important regulators of respiratory movement in mice with chronic intermittent hypoxia.

ABSTRACT:

Objective

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a prevalent respiratory disorder. Chronic intermittent hypoxia (CIH) is a key pathophysiological change linked to the development of OSAHS. The paraventricular hypothalamic nucleus (PVN) plays a role in respiratory control. This study aimed to explore a novel treatment for OSAHS through PVN stimulation.

Method

The Cre/LoxP gene expression strategy, along with the viral tracer technique and immunofluorescence staining, was employed to confirm the anatomical relationship between the PVN and the preBötzinger complex (preBötC) in mice. A CIH mouse model was established, and chemogenetics was integrated with whole-body plethysmography (WBP) to monitor the respiratory function changes in CIH mice.

Result

(1) A n

SUBMITTER: Liu L 

PROVIDER: S-EPMC12632206 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature