Negative association of C-reactive protein-albumin-lymphocyte index (CALLY index) with all-cause and cardiovascular mortality in population with CKD: the mediating role of biological age acceleration.

ABSTRACT: This study investigated the association between the C-reactive protein-albumin-lymphocyte (CALLY) index and all-cause mortality and cardiovascular disease (CVD) mortality in patients with chronic kidney disease(CKD) while exploring biological aging as a potential mediator. This study included 4,515 patients with CKD from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2010. The CALLY index was assessed only at baseline. The association between the CALLY index and all-cause and cardiovascular mortality was analyzed using Cox proportional hazards models. Additionally, Kaplan-Meier curves, smooth curve fitting, segmented linear regression, and various subgroup and sensitivity analyses were performed. Finally, the mediating role of biological age accele

SUBMITTER: Huang D 

PROVIDER: S-EPMC12632228 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature