Sesamin alleviates drug-induced hepatotoxicity via autophagy enhancement and ferroptosis inhibition.

ABSTRACT:

Background

Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure. Sesamin (Ses), a natural polyphenolic compound, possesses diverse pharmacological properties. This study was to explore the effects of Ses on APAP-induced liver injury and the underlying molecular mechanism.

Methods

In vivo, C57BL/6J mice were treated with different doses of Ses for 28 days. After overnight food deprivation, mice were intraperitoneally injected with a single dose of APAP. In vitro, the AML12 and HepG2 cells were pre-treated with Ses and then treated with APAP.

Results

Ses dramatically alleviated APAP-induced hepatocellular injury in vitro and in vivo. Proteomic analysis suggested that the differentially expressed proteins were

SUBMITTER: Ren J 

PROVIDER: S-EPMC12632232 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature